The Reds will be without Dimitar Berbatov for the Club World Cup semi-final against Gamba Osaka, but Wayne Rooney should be fit to play.
Berbatov has been laid up in bed since Tuesday morning with a virus, while Rooney picked up a knock in training later the same day.
Sir Alex Ferguson remains hopeful Rooney will make it, but Berbatov is definitely out.
"Dimitar won't play," confirmed the boss at his pre-match press conference. "He's been in bed virtually since we arrived with a virus. We're not sure where it's come from, he may have picked it up on the plane.
"Wayne was injured in training on Tuesday, but I'm hopeful he'll be okay."
The United manager also revealed that he would be turning to some of his most experienced campaigners for the Reds' last four clash on Thursday evening.
"Neville, Giggs and Scholes will all play," he said. "It's a big game situation so their experience will be very important.
"It's a competition we want to win and I'll be playing a strong team."