This time the Reds are away and the target is to stay on top of the league. The odds are 5/6 for United to gain a seventh consecutive White Hart Lane victory, 11/4 for Spurs to gain revenge for their cup exit and 9/4 for a draw.
As Sir Alex Ferguson said last week, there tends to be more goals when the teams meet in London. Another 3-1 United win is 14/1, while a repeat of last season’s 4-0 triumph is at 40/1.
Cristiano Ronaldo continues to be unstoppable but even though he has now scored in 14 of his last 16 games, you can still get odds against - 11/10 - that he'll extend the sequence in this match.
Ronny is 4/1 to open the scoring for the 10th time this term and 4/7 to end the season with the most Premier League goals, his current 19 putting him three ahead of Arsenal’s Adebayor.