United have beaten Tottenham twice this season, but Juande Ramos' unpredictable Spurs side will be keen to exact revenge at White Hart Lane.
Form Guide: Despite a resurgence under Ramos, Tottenham still haven't discovered any consistency in the league. They've taken just four points from their last four league games. However, they are unbeaten in their last six home games in all competitions. United are on a run of six straight wins, with 27 points from 30 in the last ten league games.
Ins and Outs: At this stage of the season, Sir Alex will be delighted to say that he has almost a full squad to choose from. For Spurs, Darren Bent, Benoit Assou-Ekotto (both knee), Anthony Gardner and Gareth Bale (both ankle) are all out, Juande Ramos can call on new January signings Jonathan Woodgate and Alan Hutton.
Star Men: Ronaldo is in unstoppable form for United, scoring his 26th and 27th goals of the season against Portsmouth in midweek. Stop him if you can. Tottenham's strengths lie in attacking areas, but while the focus is often on Dimitar Berbatov, Aaron Lennon proved last weekend to be a real thorn for United's defence.
What are the odds? £10 on Utd to win 3-1 (14/1) pays £140. More: Manutd.com/bet
Rivals Watch: Man City v Arsenal (Sat 12:45), Portsmouth v Chelsea (Sat 15:00).