Michael Carrick could start his first match in seven weeks when Hull City arrive at Old Trafford on Saturday.
The 27-year-old came on as a substitute on Wednesday night against his former club West Ham and Reds boss Sir Alex Ferguson says his return is "a big boost".
At his pre-match press conference at Carrington on Friday, Sir Alex also revealed Edwin van der Sar is likely to return in goal for the Reds.
"Managing Edwin to keep him fresh is important," the manager said, explaining the goalkeeper's omission from Wednesday night's match. "It's also important we give experience to Tomasz Kuszczak and Ben Foster. I'll be rotating them as the season goes on."
Wes Brown missed Wednesday's clash with the Hammers after suffering a minor ankle injury and may also be rested for Hull City's visit. However, the boss was confident the defender would be okay for United's trip to Celtic Park next Wednesday.
Sir Alex was full of praise for Saturday's opponents, describing Phil Brown's side as "amazing".
"In my programme notes, I've said that I can't believe Hull are above United in the table, and I don't mean that in a derogatory way," he said.
"I've always said when you come out of the Championship you need to invest to survive in the Premier League. But Hull have gone about it a completely different way.
"We can't treat the game lightly. We took our foot off the pedal too much in the second half against West Ham and we can't afford to do that against Hull."