United will host Championship side Queens Park Rangers in the Carling Cup fourth round.
The tie will take place at Old Trafford on Tuesday 11 November, KO 20:00 GMT.
The clubs have never met in the League Cup and last faced each other in the Premier League back in 1996.
At the time of the fourth round draw, QPR were lying fourth in the Championship. Many experts have tipped the London side to win promotion this season.
QPR boss Iain Dowie oversaw United's shock exit from the competition last season when he brought his Coventry City side to Old Trafford. The Reds lost the third round tie 2-0.
United will play QPR in the week commencing Monday 10 November. Ticket news will be published on ManUtd.com as soon as it's known, so please return regularly for updates.
Elsewhere, Arsenal and Chelsea were both handed home draws, while Liverpool travel to Tottenham Hotspur.