"Given that he has come back from a long time off, we may manage him in a different way this season so that he does not play all the midweek games, or if he plays in midweek then he won’t play at the weekend."
As he did so successfully for much of last season, Wes Brown is likely to replace Neville in what Ferguson promises will be a strong United side against Aalborg.
The one other high-profile name missing from United's 20-strong squad for Tuesday's Champions League encounter is Owen Hargreaves, who suffered a recurrence of his knee injury before the Bolton game.
"We have to manage Owen’s injury in a different way," Ferguson added. "He’s had all the treatment but his knee flares up now and again and there’s nothing we can do about it.
"The specialists say that in time it’ll go away and we hope they’re correct because he’s an important player to have: he’s a big-game player, he has experience and he’s adaptable in different positions."