The Reds go into the unknown against German champions Wolfsburg on Wednesday night, but Nemanja Vidic is confident the players will be fully prepared for the test.
As Champions League newcomers, Wolfsburg are not only preparing for their first ever game against United, it will also be their first test on the road in the competition.
The Germans go into the Old Trafford clash as group leaders - albeit on goal difference - having kicked-off their campaign in style with a 3-1 victory over CSKA Moscow.
With United having secured a battling 1-0 win against Besiktas in Turkey, Vidic is expecting a close contest on Wednesday.
"They’re the German champions and they have quality players, particularly up front," he told ManUtd.com. "It'll be a hard game and I think we’ll be the two teams fighting for top spot in the group.
"When you don’t know teams or players that well you don’t always know what to expect in games. But that’s why we have people at the club, who show us the videos before the game so we can work out exactly how they play.
"It’s a very important part of our preparation – we need to know what to expect from the players we’ll be up against because it’s the small details that can make the difference."
The Reds' defence are likely to be up against a familiar face, with former Newcastle striker Obefami Martins set to feature at some stage during the 90 minutes.
He, like his new team-mates, will be keen to put on a good display for Wolfsburg's first visit to Old Trafford, but Vidic says the Reds are up for the challenge.
"Everyone wants to play well against Manchester United and try to beat us. It’s the biggest stage to play on and other teams want to show what they can," he says.
"It’s nothing new for us – we experience it week in, week out so we’re used to it. We just have to concentrate on ourselves, work hard in training and keep improving."