Carlo Ancelotti's men will return to the league's summit if the beat Tony Pulis' side, but Darren Fletcher says the pressure is now on for Chelsea not to slip up.
"Since they beat us here at Old Trafford it’s been their title to lose," said the Reds midfielder. "We just have to keep winning and concentrating on ourselves. We’ve won our game and now it goes over to them. It’ll be tight now for the rest of the season."
United travel to Sunderland next Sunday before the visit of Stoke to Old Trafford on the final day of the season.
Chelsea face the Potters tomorrow afternoon at 16:00 BST, then travel to Liverpool next weekend, before finishing their campaign off against Wigan at Stamford Bridge.
Ryan Giggs is clinging to the hope that one of those teams will do United a favour somewhere.
"We need a favour from someone," he said. "We need to win our next two games and ultimately we need someone to take points off Chelsea. Ultimately now the pressure is on Chelsea [to win their game against Stoke]."