Vidic has missed United's last six game with a nerve problem in his right leg, but he's set to replace the suspended Rio Ferdinand for the clash with Arsene Wenger’s men.
“Everyone has come through Wednesday’s game, which is good news,” the boss told reporters on Friday morning at Carrington.
“Obviously we’re going to miss Rio because of his ban, but other than that, they’re all fit.
“The game is, to my mind looking at how the league is shaping up, is the biggest game of the season for us. With Arsenal going on a consistent run, it’s amazing how this league has changed. The team that is the most consistent will win the league now.
“Arsenal’s current form has been very good, so it’s a massive game for us. If Chelsea win their game in hand on us then they can go four points in front.
"We’re playing catch-up with that part of it, but Sunday’s game is of most relevance to us because both teams have a real chance of winning the league."