The first leg will take at the Amsterdam ArenA on Thursday 16 February, KO 18:00 GMT, with the second leg at Old Trafford on Thursday 23 February, KO 20:05 GMT. Ticket prices for the home game have now been announced.
The Reds were paired with the Dutch giants in Friday's draw, a repeat of the UEFA Cup matches in 1976 when a 1-0 deficit from the away game was overturned 2-0 in the second leg in Manchester. United have also competed in the pre-season Amsterdam Tournament on four occasions, winning it in 2006, and Edwin van der Sar's testimonial took place at the Amsterdam ArenA in August, featuring several Reds in a side managed by Sir Alex.
"Ajax are a good team and I've never faced them in competitive European football," the manager told ManUtd.com. "I'm looking forward to it."
Frank De Boer's side have a great pedigree, having won the European Cup/Champions League four times and the European Cup-Winners Cup and UEFA Cup once. The dates for the fixtures in February will be confirmed soon. The victors will progress to meet