United's first choice back five were all missing in the FA Cup win over Southampton, but the boss hopes to be able to call upon his regulars for the clash at Old Trafford.
"Vidic should be alright. Rio [Ferdinand] started running on Thursday and hopefully will be okay by Tuesday," revealed the boss who rested goalkeeper Edwin van der Sar for the trip to St Mary's.
"Rafael should also be okay, he got the all-clear on Friday [after concussion at Blackpool] and Patrice Evra had a family bereavement so we left him out at Southampton.
"We should have our back four back against Villa."