Edwin van der Sar has been given the weekend off, while Patrice Evra (family bereavement) and Rafael (concussion) will not be travelling. Michael Carrick, who has been struggling with an ankle injury, is expected to be available providing he comes through training on Friday.
“Michael will train today and hopefully he will be okay to travel,” the boss told reporters at his pre-match press conference.
“We picked up one or two bruises at Blackpool the other night - it was quite a physical game, but we’ll still take a strong squad because it won’t be an easy match; away games in cup ties never are.
“I went to see Southampton play Oldham earlier this month and they won 6-0. They're having a good season. They play good football and I'm sure they'll have a go."
Sir Alex has a decision to make on who takes over in goal for the Reds with new signing Anders Lindegaard and Tomasz Kuszczak both vying for a starting spot.
"It's a possibility [a debut for Anders],” confirmed the manager. “He and Tomasz will both travel."