The club have confirmed that goalkeeper Anders Lindegaard will undergo knee surgery on Thursday.
The operation will keep the United stopper on the sidelines for the next five weeks.
Since signing for the Reds in January, the Dane has made two appearances in goal. His debut came in the 2-1 FA Cup win at Southampton and he kept a clean sheet in the next round victory over Crawley Town at Old Trafford.
United have confirmed that young stopper Ben Amos has been recalled from his loan spell at Oldham Athletic as cover.