Sir Alex insists his side will go all out for victory against Blackpool on Sunday, but the boss confirmed he will make changes to his team with the Champions League final his primary focus.
Having wrapped up a record 19th title last weekend, the pressure will be off for the Reds when they step out at Old Trafford against Ian Holloway's men who are fighting to escape relegation.
Sir Alex's team selection will be under intense scrutiny when it is announced on Sunday, but the boss insists whatever team he fields his players are determined to round the campaign off with a win.
"Obviously everybody expects me to leave players out and that will be the case. I have to think about next week [the Champions League final]," said Sir Alex at his pre-match press conference.
"I have to juggle the balls and make sure I get the right mix and keep the right energies for Barcelona.
"There are players who need a game anyway. Darren Fletcher, Paul Scholes and Anderson will all play. So will Berbatov, Evra and Van der Sar.
"We'll do our fairest to make sure there's no criticism of the club," he added.
"The only thing you could be criticised for is if you lose a game and it affects other teams. That's when you should be put under scrutiny for the team you picked.
"Against Hull [in 2009] we played all the young players and we won 1-0, so there was no reason to criticise the selection on that occasion. This time it will be the same again. We have to make sure we win."