The Reds are still smarting from the shock FA Cup defeat the Yorkshiremen inflicted at Old Trafford in January 2010 and will aim to avenge that result by blending youth and experience.
French prospect Pogba picked up a slight knock in the Reserves' 2-1 win against Rochdale last Thursday but is in line for his senior debut. Although it promises to be a hostile occasion, Sir Alex has no qualms about fielding the talented midfielder.
"He's got a slight injury," the boss said, speaking at the launch of the club's new partner, Malaysian snack giants Mister Potato. "It's not too bad, though. So he wasn't available for Sunday but he should be able to play on Tuesday and I intend to play him against Leeds United."
Sir Alex also revealed there is no prospect of Pogba being loaned out this season, despite recent reports of interest from Burnley. The teenager could, however, be farmed out in 2012/2013. For now, though, he'll remain at Old Trafford to continue his development.
"It's more difficult to loan a boy of 18 who's come from France," explained the manager.
"We prefer to keep him with us until we find he's mature enough to possibly go on loan. Maybe next year that could be an option but we're definitely expecting him this season to stay with Manchester United."