Sir Alex Ferguson thinks Jonny Evans is a strong contender after a fine campaign but a number of names are in the frame. Nani won the award in 2011, emerging as the choice of his team-mates.
Javier Hernandez won the Sir Matt Busby Player of the Year trophy and fans' voting ends on 1 May for this year's award, with the field again wide open.
"I think Jonny is in the running, to be honest with you," said Sir Alex. "As far as I can gather.
"There's quite a few players [in contention]. David De Gea's form recently has been brilliant. Rio Ferdinand has had a great season, one of his best at the club. There's Michael Carrick, Paul Scholes."
Wayne Rooney was the only United representative in the PFA's Team of the Year and is another obvious candidate to be honoured at the ceremony, which is live on MUTV on 14 May.