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Date, time and coverage: Saturday 25 August 2012, 15:00 BST kick-off. Follow it live on ManUtd.com with text and radio and watch highlights on MUTV.
Form guide: Fulham's opening game could not have gone better as Martin Jol's side battered Norwich 5-0 at the weekend with his new players having an instant impact. Mladen Petric scored twice on his debut and confidence will be sky-high. The Reds were defeated at Everton, of course, and will look to bounce back in the first game of the season at Old Trafford.
Betting: United have been installed as strong 7/25 favourites to beat Fulham, who are rated as 9/1 outsiders (the draw is at 17/4). Despite some ongoing defensive injury concerns, the Reds will be confident about overcoming a Cottagers side who have not won at Old Trafford since October 2003. All eyes will be on the United teamsheet to see if Robin van Persie makes his first start following his move from Arsenal. The Dutchman is 3/1 to score first and 17/20 to notch at any time. Register here with bwin to place up to £20 in free bets on the match.
Ins and outs: Jonny Evans won't be fit in time to bolster the defence with Rio Ferdinand, Chris Smalling and Phil Jones still out. Michael Carrick could remain at centre-back but new boy Alexander Büttner is in the squad. Robin van Persie looks set for his first start while Ryan Giggs, Ashley Young, Anderson and Rafael are among the options if the boss wants to make changes. Clint Dempsey will again be left out for Fulham after agitating for a move to Liverpool. Zdenek Grygera is fit but Kerim Frei and Philippe Senderos miss out.