Date, time and coverage: Sunday 2 September 2012, 16:00 BST kick-off. Live on Sky Sports. Follow it live on ManUtd.com with text and radio commentary.
Form guide: United bounced back from the 1-0 defeat at Everton with a hard-fought 3-2 success against Fulham in the first home game of the new season. The Saints were unlucky to be edged out of a five-goal thriller at Manchester City on the opening weekend but followed it up with a disappointing 2-0 home reverse to Wigan. A 4-1 Capital One Cup mauling of Stevenage in midweek suggested they have not let it affect their confidence.
Betting: bwin have United as 53/100 favourites to get the job done against 5/1 shots Southampton, while draw is priced at 3/1. The Reds were 2-1 winners at St Mary’s in an FA Cup fourth-round tie between the sides in January 2011 and a repeat is available at 27/4. Meanwhile, after his stunning goal against Fulham, Robin van Persie is 7/2 to break the deadlock on the south coast, with Shinji Kagawa also sure to have plenty of support at 6/1. Register online with bwin and claim up to £20 in free bets with your first deposit.
Last meeting: United came from behind to win the afore-mentioned cup tie, with Michael Owen levelling the scores after a Richard Chaplow cracker for the Saints. Javier Hernandez grabbed the winner with a quarter of an hour remaining.
Ins and outs: Wayne Rooney and Ashley Young are missing after picking up injuries against the Cottagers but Jonny Evans should be fit enough to return