The Frenchman feels the Portuguese star will be welcomed back to Old Trafford by the supporters who worshipped him during his United days and still regularly chant his name.
The tie of the Champions League last 16 promises to provide two spectacular matches between the famous clubs and Evra is convinced the Reds can progress and remain on the road to Wembley.
"It's not an easy one as Madrid are a big team," the left-back told MUTV during a Christmas visit toThe Christie and the Royal Manchester Children’s Hospital. "On a positive front, I think everyone is going to be ready for that game.
"It's a big game and everyone will be wanting to play well. It's not easy but we can do it.
"Also, I'm happy to see Ronny back at Old Trafford. I think the fans will be very nice with him as he did a fantastic job when he was playing for United. I just hope, against us, he will do nothing and we are going to win against Madrid.
"It's a tough draw but we can do it."