Persie brace rescued the Reds and earned Sir Alex's men the three points. The fixture was one of the first instances this season United have employed the diamond formation and was also notable for providing the platform for Tom Cleverley's long-awaited Champions League debut.
Did you know? United's last Champions League outing, at Galatasaray, was the first time in 20 European games Sir Alex's men failed to score.
Opposition boss: Cluj may be on the verge of sealing a historic place in the Champions League knockout rounds, but their good progress in Europe hasn't masked problems on the domestic front. Ioan Andone was in charge when United went to Romania in early October but he was shown the door later that month and ex-Hearts boss Paulo Sergio in the hot seat.
Star man: Senegalese forward Modou Sougou has laid on exactly half of the Romanian side's eight goals in this season's Champions League competition and also netted one of his own. It's also worth keeping an eye on Rui Pedro, scorer of seven goals in his last six games.
Whistle blower: Italian referee Daniele Orsato will be in charge of only his third Champions League fixture on Wednesday. At just 37, the Vicenza-born official is younger than both Ryan Giggs and Paul Scholes.
Rivals watch: Cluj must better Galatasaray's result in Braga to qualify as runners-up in Group H. Elsewhere, Manchester City are definitely out of the Champions League and have to beat Borussia Dortmund in Germany (and hope Ajax don't beat Real Madrid) to reach the Europa League knockout stage.