O’Neill has won just three of his 22 games in charge of three different clubs against Sir Alex, though one of those was en route to League Cup glory with Leicester in 1996/97.
And his 1-0 win with Villa in December 2009 was the last time United failed to score in a home league game.
Want to see the game live at Old Trafford? A limited number of returned tickets are available – visit manutd.com/tickets to purchase.
Martin O'Neill's managerial record against Manchester United:
Sunderland (Dec 2011 - present)
League: Lost 1
Aston Villa (Aug 2006 - Aug 2010)
League: Won 1, Drew 2, Lost 6
FA Cup: Lost 2
League Cup: Lost 1
Leicester City (Dec 1995 - Jun 2000)
League: Won 1, Drew 3, Lost 4
League Cup: Won 1
Overall (22 games)
Won 3, Drawn 5, Lost 14