The attacking pair missed out on the 4-3 Boxing Day thriller but, with Shinji Kagawa also a possible inclusion as a substitute, there should be more forward options open to the boss.
Wayne Rooney's injury is improving but he will again miss out while Ryan Giggs is unlikely to feature despite his superb second-half display against the Magpies.
"I can't give you an update on the injuries as it's only two days on from Wednesday and there were issues with a soft, tiring pitch," Sir Alex said at his press conference. "We need to assess players like Paul Scholes and Ryan Giggs as I think, at their age, it took a lot out of them.
"We're hoping maybe Young will be ready and Daniel Welbeck should be ready. He was ill on Tuesday night but I think he should be okay. At least that's a couple of bodies back fresh for us. We'll just assess the rest in terms of tiredness.
"All the players are key now as we're picking up one or two injuries. Rooney is out for at least another two games. He was a bit better yesterday. We're going to assess Phil Jones but I don't think he'll be ready."
Shinji Kagawa enjoyed a work-out on the field before the 4-3 win against Newcastle, even though he was not part of the matchday squad.
"Shinji wanted to do a warm-up and training on the pitch and he is getting close," explained Sir Alex. "I'll see what he's like today and I could maybe put him on the bench tomorrow depending on who is available.