The champions face an exacting examination at the Emirates...
Date, time, and coverage
Sunday 22 January, 16:00 GMT kick-off. Live on Sky Sports. Also follow live on ManUtd.com with text and radio commentary.
United have steadied the ship since the consecutive defeats to Blackburn and Newcastle with wins against Manchester City (in the FA Cup) and Bolton. The Reds have only been beaten once on the road all season in the Barclays Premier League but that was in the last away fixture at the Sports Direct Arena. The Gunners have lost their last two games and five of the last 11 fixtures in all competitions. However, their home form has been pretty impressive as only one side has left the Emirates Stadium with three points this term - Liverpool in the opening league game at the North London venue.
Ins and outs
Sir Alex still has a number of absentees to deal with including Nemanja Vidic, Fabio and Michael Owen. Chris Smalling, Phil Jones and Jonny Evans are back in the fold and Tom Cleverley and Ashley Young have returned to light training. Arsenal have a doubt over returning legend Thierry Henry (calf) but key defender Thomas Vermaelen is tipped for a comeback. Arsene Wenger has had problems at full-back with the likes of Kieran Gibbs, Bacary Sagna and Carl Jenkinson out while Gervinho and Marouane Chamakh are away on African Cup of Nations duty and Mikel Arteta has been ruled out. Lukasz Fabianski is available again.
Arsenal will want to forget their visit to Old Trafford in August when they were on the wrong end of an incredible 8-2 scoreline with Wayne Rooney scoring a hat-trick and Young