The United youngster, born and raised in Salford, gave his side a lead with a tidy finish in the 21st minute before goals from Yohan Brouckaert and Laurent Depoitre turned the game on its head, leaving Antwerp four points off top spot in fifth place.
Giverin has now completed 13 full matches for his temporary club this season, where Reds team-mate Gyliano van Velzen is also on loan. The Dutchman was an 84th minute substitute on Saturday.
Elsewhere, Fabio was ineligible to face parent club United as QPR lost 3-1 at Old Trafford on Saturday. The Brazilian, who returned from injury last weekend, hopes to feature on Tuesday when the Hoops travel to Sunderland under new manager Harry Redknapp.
In the Championship, Ben Amos was dropped for Hull City’s 1-0 defeat to Burnley with manager Steve Bruce favouring new loan signing David Stockdale. Reds midfielder Robbie Brady impressed
Barclays Premier League
Fabio - QPR
Ben Amos, Robbie Brady - Hull City
Michael Keane, Jesse Lingard - Leicester City
Joshua King - Blackburn Rovers
Reece Brown - Coventry City
John Cofie - Sheffield United
Sean McGinty - Carlisle United
Belgian Second Division
Luke Giverin - Royal Antwerp
Gyliano van Velzen - Royal Antwerp