Date, time and coverage: Tuesday 20 November, 19:45 GMT kick-off. Live on Sky Sports in the UK. You can also follow it live on ManUtd.com with text and radio commentary.
Form guide: United secured qualification to the UEFA Champions League knockout stages as Group H winners on Matchday 4, securing a 3-1 win in Braga to maintain a perfect record in this season’s competition. As a result, Sir Alex Ferguson can afford to rotate his squad in Istanbul ahead of two Barclays Premier League clashes in five days against QPR and then West Ham. In contrast, Galatasaray are tied for second place with CFR Cluj and have everything to play for. The Turks are on a poor run of form, though, having won just three of their last 10 fixtures in all competitions.
Betting: A number of youthful Reds boarded the flight to Istanbul on Monday with many first-team regulars, including Robin van Persie and Wayne Rooney, left at home to rest. In their absence, striker Danny Welbeck seems a likely starter and might be worth backing to score first at the Ali Sami Yen Spor Kompleksi. You get odds of 6/1 with bwin.
Ins and outs: Wholesale changes are expected with only six players who featured during the 1-0 defeat to Norwich City travelling to Turkey. The boss has previously stated that Phil Jones will return from injury, while Scott Wootton is likely to be at centre-back in the absence of the rested Rio Ferdinand and Chris Smalling. Nani (hamstring), Shinji Kagawa (knee) and Jonny Evans (groin) are unavailable. Galatasaray might recall former Bolton Wanderers striker Johan Elmander after the Swede returned from injury against Karabükspor at the weekend.
Last meeting: Michael Carrick’s early goal, his first in Europe since netting against Wolfsburg