The Reds striker missed last Saturday's trip to Norwich City with tonsillitis and while he might have been rested from Tuesday's game against Galatasaray anyway, with Champions League progress already assured, he admits the second loss was also hard to take.
"We were still disappointed to lose the game, even though we'd already qualified in the Champions League as group winners," Wayne said on Friday.
"Obviously last week [at Norwich] was a massive disappointment for us. After losing that one, this QPR game couldn't have come quickly enough. We're looking to get back out there in the league and try and get the three points."
Rooney acknowledges the extra incentive provided by this weekend's order of fixtures, with current league leaders Manchester City not playing until Sunday when they meet Chelsea.
"If we can get the three points, that will take us to the top again. It might only be for 24 hours but it's always great to be there," he contemplated, before reminding the fans it's far from a formality.
"QPR last season made it difficult for us. They went down to ten men early on and got players behind the ball and made it difficult. I'm sure it will be the same this season.
"They haven't got a manager at the moment but I'm sure whoever does take over from Mark Hughes will get them organised to play that way.
"We just have to work on what we think is the best way to win the game and concentrate on ourselves.