Date, time and coverage: Sunday 7 October, 16:00 BST kick-off. Live TV coverage on Sky Sports. Live text and radio commentary on ManUtd.com.
Form guide: United can ill afford another loss after Tottenham inflicted a second defeat of the season last time out. The Reds bounced back to register a second successive win in the Champions League, at CFR Cluj on Tuesday, but Sir Alex's side had to come from behind to take the points once again. Newcastle produced a campaign-best performance against Bordeaux in the Europa League, winning 3-0, and have only lost once this term (at leaders Chelsea). The Magpies have won four out of five home clashes, only dropping points against Aston Villa.
Last meeting: Last month's Capital One Cup tie went the way of the Reds courtesy of goals from Anderson and Tom Cleverley at Old Trafford. Papiss Cisse pulled one back for the Magpies but a 2-1 triumph was fully merited. The last trip to Tyneside was one to forget as the hosts ran out convincing 3-0 victors in January, Phil Jones' last-minute own goal compounding United's misery.
Ins and outs: There are question marks over several areas of the side. David De Gea and Anders Lindegaard continue to share goalkeeping duties while there must be a temptation to start both Wayne Rooney and Robin van Persie after they linked up so effectively in Romania. But the biggest debate will centre around the midfield with Paul Scholes, Michael Carrick and Ryan Giggs back in the mix after missing the European journey. Danny Simpson returned from injury on Thursday but Steven Taylor must be a doubt, along with Fabricio Coloccini. Hatem Ben Arfa sat out the win against Bordeaux but will start in midfield, while Steve Harper looks certain