Date, time and coverage: Wednesday 31 October, 19:45 GMT. Live TV on Sky Sports in the UK. Live text and radio commentary on ManUtd.com.
Form guide: United closed the gap at the top of the Barclays Premier League table with the entertaining 3-2 victory against Chelsea on Sunday. The previous round of the Capital One Cup saw United progress past Newcastle 2-1 while Chelsea demolished an under-strength Wolves 6-0 at Stamford Bridge.
Ins and outs: Sir Alex will keep everybody guessing with the nature of his line-up although he did confess he felt both managers would make changes. Senior figures such as Rio Ferdinand, Wayne Rooney and Robin van Persie could be rested with one eye on Saturday's match with Arsenal so the likes of Scott Wootton, Anderson, Darren Fletcher and Ryan Giggs could come into the boss' thinking. Chelsea are still missing John Terry and Frank Lampard and have included youngsters George Saville and Nathan Ake in their squad. Branislav Ivanovic and Fernando Torres sit out their one-match bans.
Betting: Two red cards were shown in Saturday's bad-tempered league encounter and a repeat is at 10/1, while one red to be brandished is a 3/1 chance. Both teams will make plenty of changes and considering United’s superior strength in depth, particularly in midfield and up front, the Reds look a superb price at 21/10 to leave Chelsea spitting feathers once more. Punters seeking a flutter on what promises to be another enthralling encounter can open a bwin account here and claim up to £20 in free bets.
Last meeting: Of course, United triumphed at the weekend after taking an early lead through a David Luiz own goal and van Persie's smart finish. Juan Mata and Ramires hauled the Blues level with efforts either side of half time, only for Ivanovic and Torres to both see red. Javier Hernandez pounced to grab the winner with 15 minutes remaining.