Date, time and coverage: Tuesday 2 October, 19:45 BST kick-off. Live on ITV1. Also follow it live on ManUtd.com with text and radio commentary.
Form guide: United travel to Romania on the back of a disappointing 2-3 home defeat to Tottenham, yet potentially boosted by a second-half display which framed the Reds' best form of the season so far. Victory over Galatasaray on Matchday One has United on three points in Group H, but trailing CFR Cluj on goal difference after the Romanians' shock 2-0 win at Braga on the same night. Cluj's domestic form has been patchy at best, with just four wins from ten league games this term, though the most emphatic victory came in Saturday's 5-1 thumping of Gloria Bistrita.
Last meeting: The two sides have never met, but United can boast a perfect record in Romania, having previously beaten Dinamo Bucharest (2-1 in 2004) and Otelul Galati (2-0 in 2011) in Bucharest.
Ins and outs: United's defensive injury woes show no signs of abating, with Chris Smalling, Phil Jones and Nemanja Vidic still sidelined. Further up the field, Wayne Rooney may be ready to return to the starting line-up after his impressive 45-minute cameo against Tottenham, but Michael Carrick, Ryan Giggs, Paul Scholes and Antonio Valencia have all remained in Manchester. Cluj coach Ioan Andone has no major injury concerns going into Tuesday's meeting, but is keeping an eye on the fitness of striker Pantelis Kapetanos.
Opposition boss: Ioan Andone has previous with United, having helmed Dinamo Bucharest during the Reds' comfortable 2004/05 qualifying round triumph. A dominant, hulking centre-back in his playing days - which yielded 55 international caps - the Romanian's side is built in his mould, with a strong emphasis on defensive stability, laying the foundations for quick counter-attacks.
Star man: Rafael Bastos scored both goals against his former side, Braga, on Matchday One, and the lively Brazilian attacker is a key component in his side's fleet-footed breaks.