The Spanish keeper made a string of fine saves, the best of which was a world-class stop to thwart his fellow countryman Fernando Torres in the first half.
By improvising and using his feet to block a couple of difficult attempts by the home side, the youngster again showed his quality after also excelling at Stamford Bridge in last term's 3-3 draw.
Almost 5,500 fans plumped for De Gea, earning the former Atletico Madrid man 52 per cent of the votes with van Persie having to settle for second place.
The Dutch striker's shot crashed off an upright and into the net off David Luiz for the opener before he confidently converted a driven centre by Antonio Valencia to double the lead. After his spin and pass released Ashley Young in the build-up to Branislav Ivanovic's red card, it was also van Persie's shot, touched onto the woodwork by Petr Cech, that ultimately led to Javier Hernandez finishing off Rafael's dangerous ball into the six-yard box.
Wayne Rooney came third in our poll - ahead of defenders Rafael and Rio Ferdinand after another eye-catching performance in a midfield role.