Date, time and coverage: Saturday 29 September, 17:30 BST kick-off. Live TV coverage on ESPN. Live text and radio commentary on ManUtd.com.
Form guide: Wednesday’s 2-1 win over Newcastle United in the Capital One Cup was Manchester United’s sixth consecutive triumph in all competitions, following defeat to Everton on the opening night of the Barclays Premier League season in August. The Reds have not lost in 26 previous matches against Tottenham at Old Trafford, a record that began following the 1989 defeat in the old First Division. Spurs, however, should pose serious problems on Saturday. The North London club are unbeaten in four and have shown recent signs of improvement under new manager Andre Villas-Boas.
Last meeting: Sir Alex Ferguson surpassed Sir Matt Busby's tenure by taking charge of his 986th league match, as United maintained the pressure on league leaders Manchester City with a 3-1 win at White Hart Lane. Ashley Young scored two spectacular strikes after a first-half opener from Wayne Rooney.
Ins and outs: Anders Lindegaard might reclaim his place after David De Gea started in midweek, and Sir Alex is also likely to recall Rafael, Jonny Evans, Rio Ferdinand and Patrice Evra. Paul Scholes, Michael Carrick and Shinji Kagawa are expected to feature in midfield after a rest, while Wayne Rooney could start alongside Robin van Persie for the first time after the former returned from injury on Wednesday. Spurs are without Scott Parker, Younes Kaboul and Benoit Assou-Ekotto, while Kyle Naughton and Emmanuel Adebayor are both doubtful.