Date, time and coverage: Wednesday 26 September, 19:45 BST kick-off. Live TV coverage on Sky Sports. Live text and radio commentary on ManUtd.com.
Form guide: United are in splendid form after responding to the defeat at Everton with five straight wins. The four victories in the Barclays Premier League have taken the Reds to second in the table behind Chelsea. Newcastle have followed up last term's impressive campaign by also starting well. Sunday's 1-0 win against Norwich City moved the Magpies up to 10th and their fighting spirit earned a valuable point at Everton recently.
Last meeting: It was a January night to forget for the Reds as Newcastle made it four points out of six from the two league encounters with a deserved 3-0 success at the Sports Direct Arena. Demba Ba opened the scoring before Yohan Cabaye's explosive free-kick and Phil Jones' late own goal compounded the visitors' misery.
Ins and outs: Both teams are likely to field stronger starting XIs than would sometimes be the case in this competition. Alexander Büttner, Anderson and Darren Fletcher look likely to feature, while youngsters such as Scott Wootton, Nick Powell, Jesse Lingard, Ryan Tunnicliffe, Davide Petrucci, Bebe, Federico Macheda, Joshua King, Robbie Brady and Michael Keane will also be in contention. Alan Pardew has confirmed Cheick Tiote and Fabricio Coloccini should play as they aim to get back to full fitness, while Rob Elliot is expected to continue in goal. Danny Simpson will miss out on another Old Trafford reunion due to injury.