Lou Macari thinks United will still clinch a record 20th crown despite slipping up against Manchester City on Monday night.
The 2-1 defeat cuts the gap at the top of the Barclays Premier League to 12 points with seven games remaining and the Reds need to get back on track with tricky away matches at Stoke City and West Ham to follow.
Speaking to MUTV after the derby, the former Old Trafford favourite thinks the loss will not have a huge impact on the destiny of the title.
"I think it doesn't matter who we play against with the position we're in now," stated Macari. "A 12-point start on the team below you with that many games left means we're almost home and dried.
"We've only lost four games all season so why are we going to lose four in the space of seven games? It's not going to happen. There's no doubt we're not playing at our very best but who's to say we're not going to pick up at Stoke on Sunday and have a change in fortune until the end of the season?
"The guys are not going to throw it away now, especially after what happened last season. It's almost impossible as there are not enough games to make that many mistakes."
Macari managed Stoke twice and appreciates it will be a hostile atmosphere at the Britannia Stadium as the Potters are battling against relegation.