Date, time and coverage: Monday 8 April, kick-off is 20:00 BST. The match will be shown live in the UK on Sky Sports and you can follow it via ManUtd.com's exclusive text and radio commentaries.
Form guide: Manchester United's last defeat in the Barclays Premier League was way back in November at Norwich. The Reds have also rattled off 12 consecutive victories in the division at home following the 3-2 reverse to Tottenham. However, the FA Cup exit at the hands of Chelsea did represent a rare domestic defeat. Manchester City are playing well and have won five of their last six games, with the loss at Everton being the only blip. Those five successes also featured five clean sheets.
Ins and outs: Rafael and Wayne Rooney are back in training and expected to feature but Jonny Evans and Nemanja Vidic need to prove their fitness. Paul Scholes remains out but Sir Alex Ferguson will have a wealth of options at his disposal. Vincent Kompany is back for City while Micah Richards and Maicon competed at Under-21 level recently but Jack Rodwell could miss out.
Betting: Bwin are offering money back on single first goalscorer bets if a penalty is awarded. Robin van Persie (6.5) and Wayne Rooney (7.0) will be popular with Reds fans. United are 2.15 favourites to win with City priced at 3.20 and the draw the outsider of the three at 3.40.
Last meeting: A thriller at the Etihad Stadium saw United take a two-goal lead with virtually identical Wayne Rooney finishes. After Ashley Young had a goal wrongly ruled out for offside, the champions hit back through Yaya Toure and Pablo Zabaleta. Lesser teams would have crumbled as City clearly had the momentum but Robin van Persie's deflected free-kick earned a huge three points in the closing stages.