The striker came on in the second half of the Reds' opening day win at Swansea last weekend having been hampered by hamstring and shoulder injuries during pre-season.
Moyes confirmed Rooney had recovered from the minor knock he picked up during his run-out at the Liberty Stadium and could be a starter against Jose Mourinho's men at Old Trafford.
"Wayne's got a good chance of playing. He has good chance of starting," the manager told reporters on Friday.
The Scot added that he is relishing taking charge of the Reds for the first time in a league game at the Theatre of Dreams.
"There has been a lot of things I have been looking forward to - like taking the team on tour and leading them out at Wembley. But to do it at Old Trafford for the first game against Chelsea is a thrill for me, it really is," he said.
"It would have been [a thrill], no matter who we were playing. It is just part of my job though and once you do it, you get on and do your job. It is a great honour to be manager of Manchester United. I don't know anybody who wouldn't want to be in this position."