The Japan international has been ill during the Reds’ preparations for the visit of the Magpies but with Wayne Rooney suspended, the manager will be keen to have as many options as possible for the clash which kicks off at 12:45 GMT.
"Shinji has had a sickness and has been unwell," Moyes reported at his pre-match press briefing on Friday. "I will see how he is tomorrow, we hope to have him available, but he wasn’t too good after the game."
The Reds are looking to move on from Wednesday's defeat to Everton as Alan Pardew brings his side to Old Trafford. Newcastle’s own unbeaten run ended in midweek when they lost 3-0 at Swansea City.
"It could be a bad time to face Newcastle, but they also had a defeat to Swansea," said Moyes. "They are coming to Old Trafford and we will make it as hard and as difficult for them as possible."
Meanwhile, Moyes feels his side can build on a performance in which the Reds were twice denied goals by the woodwork.
"There were chances in the [Everton] game that we didn't take and the result could have quite easily have been different. I think if they [the fans] watched the game then they will have got lots of belief from it.