Robin Van Persie is out of action for around a month with a thigh injury.
David Moyes confirmed at his pre-match press briefing on Friday that the Dutch striker will miss around four weeks.
The 30-year-old returned to action last Saturday after missing four games with toe and groin problems, and the boss reflected on how he will not be able to pick Van Persie together with Wayne Rooney over the upcoming part of the season.
“It is unfortunate, because if you look at our record with Wayne and Robin in the team it is very good and we have not had them for a period,” Moyes told radio reporters.
Van Persie has scored 10 goals for the Reds this season, most recently when he grabbed the winner against former club Arsenal before sitting out the next four games with injury.