Speaking at his pre-match press briefing on Monday afternoon, the manager said that domestic defeats to Everton and Newcastle United had hurt the players, but he predicted they will respond positively in the final Group A fixture.
"The players are hurting because they are used to winning," Moyes declared. "When they don't win, that hurts them as they care very much about their team and their club. They are good lads and will respond in the right way.
"I take complete responsibility for the results. Fortunately, they've been good in the Champions League but not in the Premier League. I take the responsibility. I would like them to be much better and have no doubt they will.
"I think in recent games we haven't quite finished the games in the way I'd like to. I have tried to make changes to improve it and that hasn't quite happened."
The 5-0 win over Bayer Leverkusen on Champions League matchday five secured progress to the last 16, and Moyes is looking for another positive result to ensure United win Group A.
"It's important to give ourselves the best possible chance in the next round," he added. "The big job was to make sure we qualified from the group and that part is done. Hopefully we can finish the group unbeaten and, if we do that, it will see us through [as group winners]."