Ryan Tunnicliffe was handed his Barnsley debut just a day after signing on loan, though the United youngster could do little to prevent a 5-3 defeat to Bristol City.
The 20-year-old played a full match for the Championship strugglers and almost scored on five minutes when a 25-yard shot was saved by Tom Heaton, who made a number of fine stops throughout the match.
The former Reds goalkeeper was also on hand to thwart Tunnicliffe's driving run in the second half, diving at his feet before a goalmouth scramble saw Chris O'Grady pull a goal back for Barnsley.
David Flitcroft's Tykes have been in good form of late after winning eight of their last nine league and cup fixtures but Saturday’s defeat means they drop to 21st in the table, just two points above the relegation zone.
Elsewhere, Michael Keane kept a clean sheet as Leicester City recorded a goalless draw with Blackpool at Bloomfield Road, where former United favourite Paul Ince took charge of his first home match as Tangerines manager.