Former England manager Graham Taylor and ex-Barnsley boss Simon Davey will conduct the draw at 17:55 GMT. By that time, six of the eight fifth-round ties will be complete, leaving only the Reds and the Royals to battle it out at Old Trafford and Middlesbrough to host either Chelsea or Brentford (who play their fourth round replay on Sunday).
United will be represented in the draw by ball no.7, with the sixth-round fixtures scheduled to be played on the weekend of 9 and 10 March.
The draw will be broadcast on ITV, ESPN and www.thefa.com/fatvlive.
Sunday 17 February, 17:55 GMT
1) Wigan Athletic
3) Oldham Athletic or Everton
5) Blackburn Rovers
6) Manchester City
7) Manchester United or Reading
8) Middlesbrough or Chelsea