Date, time and coverage: Wednesday 13 February, 19:45 GMT kick-off. Live on Sky Sports. Also follow it live on ManUtd.com with text and radio commentary.
Form guide: For all the talk of Real Madrid's domestic struggles, with Jose Mourinho's side sitting in third place in La Liga, the recent form has hardly been disastrous. A 1-0 defeat at Granada was a shock but that's the only reverse in the last 10 fixtures. Comprehensive thumpings of Celta Vigo, Valencia, Getafe and Granada all came during that run. United's last defeat came in the Champions League dead rubber against CFR Cluj in early December and four wins on the spin have set things up nicely for the Bernabeu, helping to extend the lead at the Barclays Premier League summit to 12 points.
Betting: Madrid are odds-on favourites with bwin to come out on top in the first leg. The Spanish side are rated 3/5 shots with the draw at 17/5 and United 18/5. Cristiano Ronaldo (7/2) heads the first-goalscorer betting and Karim Benzema (9/2) and Gonzalo Higuain (5/1) are also shorter than the visitors' leading marksman Robin van Persie (13/2).
Last meeting: A 4-3 win at Old Trafford ultimately proved fruitless with Real progressing 6-5 on aggregate but it was a compelling game that, legend has it, caused Chelsea owner Roman Abramovich to fall in love with football. Ronaldo hit a hat-trick for the visitors to prompt the home fans to sportingly give him an ovation as he was substituted while David Beckham netted twice for the Reds. After the quarter-final exit, Sir Alex's side used the remaining three league games to wrap up the title.