Did you know? The rivalry between these two giants of English and European football originates from industrial matters stemming back to the building of the Manchester ship canal in the 1880s, which bypassed the port of Liverpool and led to job losses and discontent on Merseyside.
Opposition boss: Despite making a slow start to life with Liverpool, Rodgers is beginning to see the fruits of his labour at Anfield, adding consistency and cutting edge to the neat passing game that had seen the Merseysiders fail to win several matches from dominant positions this season. Cool, calm and collected, the Northern Irishman is a keen student of the game and has previously worked under Jose Mourinho at Chelsea before spells in charge of Watford, Reading and Swansea.
Star man: Although a controversial character, Luis Suarez is ultimately one of the best forwards operating in the Barclays Premier League and will provide a stern test for United’s defence on Sunday. The Uruguayan has almost single-handedly carried the responsibility for scoring Liverpool’s goals this term, bagging an impressive 15.
Sub-plots: Unlike last season, this fixture is relatively issue-free, enabling both clubs to focus solely on the football. Of course, United hope to beat Liverpool for the second time this term and seal a first league double over the Merseysiders since the 2007/08 campaign.
Whistle-blower: Howard Webb will be the man in the middle at the weekend. The Yorkshire-based referee last took charge of this fixture in January 2011, during which he dismissed Steven Gerrard for a studs-up challenge on Michael Carrick.
Rivals watch: On Saturday, Tottenham make the short journey to QPR before Chelsea face Stoke City at the Britannia