Did you know? Each of the last five fixtures between United and Southampton have been played at St Mary's. Old Trafford last hosted the teams way back in December 2004. On that occasion, United won 3-0 thanks to goals by Paul Scholes, Wayne Rooney and Cristiano Ronaldo.
Opposition boss: The surprise sacking of Nigel Adkins, a man who took Southampton from League One to the Premier League in just two seasons, opened the door for Argentinian Mauricio Pochettino to take over. A legend at Espanyol as a player, Pochettino, 40, also managed the club - based in Barcelona - for three-and-a-half years before losing his job in November.
Star man: Southampton may lie in 15th spot but in striker Rickie Lambert they have a player with an exceptional eye for goal. Indeed, only four players – Michu, Demba Ba, Luis Suarez and Robin van Persie – have found the net more times in the league this season. A real journeyman in his earlier years (he's played in each of England's top four divisions), Lambert would love to continue his fine form by netting at Old Trafford.
Quote/unquote: “To meet Sir Alex will be a proud moment. He’s an incredible manager who has had a successful project for 25 years. But I’m worried about which Argentine wine I can take him. I worry he may end up disappointed.” – Mauricio Pochettino
Whistle-blower: Lee Mason is the man in charge on Wednesday night. The 41-year-old from Bolton has officiated one Reds game already this season, the 5-4 Capital One Cup defeat at Chelsea.
Rivals watch: Manchester City drew 0-0 at Queens Park Rangers on Tuesday night. Elsewhere on Wednesday, Arsenal host Liverpool (19:45) and Chelsea travel to Reading (20:00).