Wayne Rooney is an obvious contender after scoring the crucial two goals and he was denied a hat-trick when Saints keeper Artur Boruc came out from his goal to save at his feet. For all his attacking work, Rooney was also needed to help out in defence towards the end of the 90 minutes and made a couple of meaty challenges.
The Reds needed to be resilient at the back, particularly in the second half, and captain Nemanja Vidic was a solid presence despite picking up a booking. Fellow defender Patrice Evra shone with some tenacious play and teed up the winning goal with a flying header at the far post.
Shinji Kagawa was particularly effective in the first period and was unlucky not to score when hitting a post. The Japan international also split the visiting defence to set up Rooney's equaliser and was bright and inventive before being replaced by Nani with 17 minutes remaining.
Danny Welbeck was another who did most of his eye-catching work before the break and forced a decent save out of Boruc. The forward, playing wide, put in another good shift and kept working hard throughout.
Who will you vote for in our Man of the Match poll at manutd.com/vote?