Sub-plots: Robin van Persie will get a rough ride from the home fans due to his Arsenal connection while Spurs have the incentive of doing a rare double and arguably sneaking into the title race themselves. Midfielder Michael Carrick will come up against his former club. The Reds have an excellent record at White Hart Lane, scene of some superb wins over the years.
Whistle-blower: Chris Foy takes charge of proceedings in the capital. The experienced referee was also in charge for Tottenham's win at the Theatre of Dreams on 29 September and United's 3-1 beating of Sunderland before Christmas.
Rivals watch: Manchester City will expect to close the gap at the summit when they entertain Fulham on Saturday while Sunday's other big game sees Chelsea face Arsenal at Stamford Bridge.