Sir Alex's men found themselves 2-1 down against Wednesday night's opponents back in September before Robin van Persie rescued the Reds with a dramatic hat-trick. Kagawa remembers the match well and admits it's a thrill to play alongside the Dutchman.
"It’s not only that game at Southampton [where I've been impressed with Robin]. He’s a player who can do a crucial job to win in almost every game.
"It’s a wonderful experience for me to be able to play with him. It’s always encouraging to have players like van Persie and Wayne Rooney when you’re attacking."
Fans attending the Southampton game can read more from this interview in the official matchday programme, United Review (available for £3).
The official matchday programme is still only £3 at Old Trafford.
Fans around the world can also subscribe to have it delivered to their door.
* Kagawa interview
* Sir Alex notes
* Andy Cole column
* Irwin recalls 1995 clash
* Classic matches feature
* Much, much more