Date, time and coverage: Tuesday 5 March, kick-off 19:45 GMT. The match is live on ITV in the UK and you can also follow it via ManUtd.com’s text and radio commentaries.
Form guide: United avenged the last Barclays Premier League defeat, way back in November, with a 4-0 thumping of Norwich at the weekend, warming up for Real Madrid nicely. The European form is less impressive but the 1-0 defeats to Galatasaray and Cluj came after qualification was already assured. Real have been buoyed by consecutive victories against Barcelona, in the Copa del Rey and La Liga, and come into the game bristling with confidence.
Betting: bwin believe Real Madrid are favourites to win both on the night and qualify for the quarter-finals. Jose Mourinho's men are 15/13 with United 2/1 despite home advantage. The draw is 27/10. In terms of progressing to the last eight, Real are 8/13 and the Reds 6/5. A repeat of the first leg scoreline, 1-1, which would mean extra-time, is 6/1. Click here for more odds.
Ins and outs: Phil Jones is doubtful after hurting his ankle against Reading in the FA Cup and Rio Ferdinand has been ill. Paul Scholes has been sidelined with a knee injury but, hopefully, everybody else is fit for United. Real have included Iker Casillas in the travelling party but the Spain No1 is still unavailable so Diego Lopez will continue to deputise in goal. Pepe played in midfield at the weekend and is pushing for a start.