Date, time and coverage: Sunday 10 March, kick-off 16:30 GMT. The match is live on ITV in the UK and you can also follow it via ManUtd.com’s text and radio commentaries.
Form guide: The Reds may have been beaten in controversial circumstances in midweek but remain in imperious form domestically and unbeaten since the 1-0 defeat at Norwich in November. Chelsea did inflict one of only four losses in England this term with a 5-4 extra-time triumph in the Capital One Cup and are determined to go all the way in the FA Cup again after a title bid has faltered. The Blues were beaten in the first leg of their Europa League tie with Steaua Bucharest on Thursday but have, generally, been in good form.
Betting: bwin rate United as favourites (1.80) to win the tie with the draw priced at 3.70 and Chelsea 4.10. In terms of first goalscorer betting, Wayne Rooney and Javier Hernandez are both 5/1 (6.0)shots. Click here for more odds.
Ins and outs: Wayne Rooney, Jonny Evans and Shinji Kagawa will all hope to return to the side as Sir Alex has a number of options available once again. Javier Hernandez could be considered for a start as he has a tremendous record against the Blues. Nani is obviously eligible despite his red card against Real Madrid while Ryan Giggs and Phil Jones will miss out. Ramires, who scored in both games against United this term, sat out the trop to Romania while Juan Mata started on the bench. John Terry returned to skipper the team and Demba Ba is available again after being cup-tied in Europe.