Date, time and coverage: Monday 1 April, kick-off is 12:30 BST. The match will be shown live in the UK on ITV1 and you can follow it via ManUtd.com's exclusive text and radio commentaries.
Form guide: Manchester United are in top form domestically despite going out of the Champions League. Unbeaten since the defeat at Norwich City in November, the Barclays Premier League leaders have been as effective on the road as at Old Trafford. Saturday's 1-0 victory at Sunderland means the Reds are the first team in England's top flight to have won 25 of the first 30 league games. Chelsea have won six of their last seven games at Stamford Bridge but they slipped up away at Southampton this weekend, losing 2-1 and giving hope to sides coveting their top-four place.
Ins and outs: Paul Scholes and Phil Jones could both be available for the trip to London with Sir Alex certain to shuffle his pack following Saturday's game at Sunderland. Chelsea made seven changes for their defeat to Southampton, so the likes of Ashley Cole, David Luiz and Ramires are all set to return.
Betting: Chelsea are the favourites on their home patch with bwin pricing the Blues at 2.35 to win in normal time, with United rated 2.75 shots and the draw 3.20. To go through by any means, the capital club are 1.75 with the Reds at 1.95.
Last meeting: The Reds looked on course for the semi-finals of the FA Cup when taking an early two-goal lead at Old Trafford through Javier Hernandez and Wayne Rooney. However, Rafa Benitez's side came on strong in the second half and substitute Eden Hazard pulled one back before Ramires equalised.