The Barclays Premier League leaders can go 18 points clear of reigning champions Manchester City with success at the Stadium of Light, given Roberto Mancini's men are not in action until later in the day when Newcastle visit the Etihad Stadium.
A victory would also ensure the Reds become the first team in Premier League history to win 25 of the first 30 games of a season.
However, Sir Alex is only concerned about wresting the title back from neighbours City with the Blues coming to Old Trafford in the next league fixture after this weekend's action.
"Winning the league is important," stressed the manager. "I don't care what we win it by.
"It could be a dodgy goal off someone's backside in the last minute of the last game of the season. It doesn't bother me one bit.
"Winning the league is the issue. At this moment in time, we have a chance."